2-Hydroxybenzonitrile → 1-(3-Aminobenzo[B]thiophen-2-YL)ethanone

HRID 869376Notes

Reaction equation

[SH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[OH:10][C:11]1[CH:18]=CC=C[C:12]=1C#N>>[NH2:5][C:4]1[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[S:1][C:12]=1[C:11](=[O:10])[CH3:18]

Participants

Reactant 2

HCID 119072-Hydroxybenzonitrile

HCID 110189262-Mercaptobenzonitrile

Product 1

HCID 34342391-(3-Aminobenzo[B]thiophen-2-YL)ethanone

Procedure

The procedure was similar to step S1A, while the starting material was 2-mercapto-benzonitrile (3A) in stead of 2-hydroxy-benzonitrile.

Sources & evidence

ORD record: ord-219d724e77c74a00adddc23056690846
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08969373B2

Reaction notes

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