Water → HCID 86722236, compound

HRID 869387Notes

Reaction equation

HRID 869387 reaction equation
[C:1]([C:11]1[O:12][C:13]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([Cl:23])[C:14]=2[C:15]=1[NH2:16])(=[O:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O>CC(O)=O.OP(O)(O)=O>[Cl:23][C:17]1[C:14]2[C:15]3[NH:16][CH:3]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH2:2][C:1](=[O:10])[C:11]=3[O:12][C:13]=2[CH:20]=[CH:19][C:18]=1[O:21][CH3:22]

Participants

5

Reactant 2

HCID 962WaterHCID 86722234HCID 86722234, compound

Product 1

HCID 86722236HCID 86722236, compoundYield 93.68%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 1004Phosphoric AcidSolvent

Procedure

A mixture of 8A (1.9 g, 5.8 mmol) in AcOH (10 mL) and H3PO4 (10 mL) was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (20 mL) The yellow solids were precipitated out, collected by filtration and dried to give product 8B (1.78 g, 93.68% yield).

Workup

  1. temperaturewas refluxed for 2 hours
  2. customthe reaction
  3. customwere precipitated out
  4. filtrationcollected by filtration
  5. customdried

Sources & evidence

ORD record
ord-2557b9e3868f4298aa4b8145a3f073d9
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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