反应详情

11A (29.6 g, 0.2 mol) was dissolved in anhydrous EtOH (300 mL). To the solution was added 3-bromo-2-oxo-propionic acid (34 g, 0.17 mol). The mixture was refluxed for 2 hours, then cooled to room temperature, concentrated to dryness, dissolved with ethyl acetate, washed with saturated aqueous of NaHCO3. The organic layer was dried and concentrated to give a crude product 11B (48 g, 100% yield).

1. temperatureThe mixture was refluxed for 2 hours
2. concentrationconcentrated to dryness
3. dissolutiondissolved with ethyl acetate
4. washwashed with saturated aqueous of NaHCO3
5. customThe organic layer was dried
6. concentrationconcentrated