Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Thiazolecarboxaldehyde, 2-(1-methylethyl)- (9CI) | HCID 45083848 | — |
| Reactant | HCID 86722252 | HCID 86722252 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86722255 | HCID 86722255 | 63.9% |
Reaction Steps
A mixture of 12G (1.5 g, 5.2 mmol), 2-isopropyl-thiazole-5-carbaldehyde (1.2 g, 7.7 mmol) in THF (20 mL) was cooled to 0° C. To the mixture was added NaOH (1.5 g), then stirred at room temperature overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 14A (1.4 g, 62.9% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969373B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-bb860ab867aa427797ee077a286a45ca |
|---|
| Source note | uspto-grants-2015_03 |
|---|
