Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | HCID 86722255 | HCID 86722255 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86722256 | HCID 86722256 | 79.1% |
Reaction Steps
A mixture of 14A (1.4 g, 3.3 mmol), ZnCl2 (6 g), MeCN (10 mL), AcOH (2 mL) and H3PO4 (2 mL) was heated to 90° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water, extracted with ethyl acetate and concentrated to give 14B (1.1 g, 78% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969373B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-825a036e6540422db76d5b7a45e2bd17 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
