Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Isopropylthiazole-4-carbaldehyde | HCID 2763192 | — |
| Reactant | HCID 86722252 | HCID 86722252 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86722258 | HCID 86722258 | 94.9% |
Reaction Steps
A mixture of 12G (2 g, 7 mmol), 2-isopropyl-thiazole-4-carbaldehyde (2.2 g, 14.6 mmol), NaOH (1.5 g) and MeOH (20 mL) was heated to 50° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 15A (2.8 g, 94.4% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969373B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-c95180d3aade4f86bd59966307b6144b |
|---|
| Source note | uspto-grants-2015_03 |
|---|
