HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869415Generated: October 29, 2026
Phosphorus oxychloride → HCID 86722261, compound
https://huagongshe.com/reaction/869415
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Hydroxyl-9-bromo-2-(2-isopropyl-thiazol-4-yl)-8-methoxy-benzofuro[3,2-b]pyridine | HCID 178488261 | — |
| Product | HCID 86722261 | HCID 86722261 | 16% |
Reaction Steps
A mixture of 15C (1.2 g, 2.8 mmol) in POCl3 (10 mL) was heated to 110° C. and reacted for 30 min. TLC monitored the reaction. After the reaction completed, POCl3 in the reaction mixture was evaporated. The residue was added dropwise into ice-water. The precipitated solids were collected by filtration and purified by short column chromatography to give M15 (0.2 g, 16% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969373B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-8a7c47fadf3e4cd08f2db144cfaa9534 |
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| Source note | uspto-grants-2015_03 |
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