Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | HCID 86722262 | HCID 86722262 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86722263 | HCID 86722263 | 55.1% |
Reaction Steps
A mixture of 16A (2 g, 4.3 mmol), ZnCl2 (6 g), MeCN (10 mL), AcOH (2 mL) and H3PO4 (2 mL) was heated to 90° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water, extracted with ethyl acetate and concentrated to give 16B (1.1 g, 55% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969373B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-7357f5891e964d5ab3ca22ae9acd37d7 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
