2-Hydroxybenzonitrile → HCID 178487265, compound

HRID 869438Notes

Reaction equation

HRID 869438 reaction equation
COC(=O)[CH:4]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:7]=1[C:14](OC)=[O:15])Br.COC(=O)C(C1C=CC(Cl)=CC=1C(OC)=O)Br.[Cl:36][C:37]1[CH:38]=[CH:39][C:40]([OH:45])=[C:41]([CH:44]=1)[C:42]#[N:43].OC1C=CC=CC=1C#N>>[OH:15][C:14]1[C:7]2[C:6](=[CH:11][CH:10]=[C:9]([O:12][CH3:13])[CH:8]=2)[C:4]2[O:45][C:40]3[CH:39]=[CH:38][C:37]([Cl:36])=[CH:44][C:41]=3[C:42]=2[N:43]=1

Participants

5

Reactant 4

HCID 119072-HydroxybenzonitrileHCID 27774205-Chloro-2-hydroxybenzonitrileHCID 867222712-(4-Chloro-2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl esterHCID 867222862-(4-Methoxyl-2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl ester

Product 1

HCID 178487265HCID 178487265, compound

Procedure

The procedure was similar to step S19B, while the starting material was 28A in stead of 19A, and used 5-chloro-2-hydroxy-benzonitrile in stead of 2-hydroxy-benzonitrile.

Sources & evidence

ORD record
ord-331e211f502b40be9c3ff2f1a079ab24
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

Loading…