2-Hydroxybenzonitrile → HCID 178516964, compound

HRID 869440Notes

Reaction equation

HRID 869440 reaction equation
COC(=O)[CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12](OC)=[O:13])Br.COC(=O)C(C1C=CC(Cl)=CC=1C(OC)=O)Br.[F:34][C:35]1[CH:42]=[CH:41][C:38]([C:39]#[N:40])=[C:37]([SH:43])[CH:36]=1.OC1C=CC=CC=1C#N>>[OH:13][C:12]1[C:7]2[C:6](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]2[S:43][C:37]3[CH:36]=[C:35]([F:34])[CH:42]=[CH:41][C:38]=3[C:39]=2[N:40]=1

Participants

5

Reactant 4

HCID 119072-HydroxybenzonitrileHCID 115075112-(2-Methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl esterHCID 867222712-(4-Chloro-2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl esterHCID 867222894-Fluoro-2-mercaptobenzonitrile

Product 1

HCID 178516964HCID 178516964, compound

Procedure

The procedure was similar to step S19B, while the starting material was 29A in stead of 19A, and used 4-fluoro-2-mercapto-benzonitrile in stead of 2-hydroxy-benzonitrile.

Sources & evidence

ORD record
ord-b877b1bc464940c3aa7e8dd37fa33cde
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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