3-Chloro-benzofuro[3,2-c]isoquinoline-5-ol → 5-Chloro-9-fluoro-benzothieno[3,2-c]isoquinoline

HRID 869441Notes

Reaction equation

HRID 869441 reaction equation
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2[S:12][C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=3[C:4]=2[N:3]=1.[Cl:20]C1C=C2C(C3OC4C=CC=CC=4C=3N=C2O)=CC=1>>[Cl:20][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2[S:12][C:13]3[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=3[C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 1785169623-Chloro-benzofuro[3,2-c]isoquinoline-5-olHCID 178516964HCID 178516964, compound

Product 1

HCID 867222905-Chloro-9-fluoro-benzothieno[3,2-c]isoquinoline

Procedure

The procedure was similar to step S19C, while the starting material was 29B in stead of 19B.

Sources & evidence

ORD record
ord-30fd2875355b4173af2db4769d169563
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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