Formamide → HCID 178518017, compound

HRID 869442Notes

Reaction equation

HRID 869442 reaction equation
[NH2:1][C:2]1[C:3]([C:8]([OH:10])=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH:11]([NH2:13])=O>>[N:1]1[C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[C:8]([OH:10])=[N:13][CH:11]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 738363-Aminopicolinic acid

Product 1

HCID 178518017HCID 178518017, compound

Conditions

Temperature
170 °C

Procedure

3-Aminopicolinic acid (A-1) (30 g, 217 mmol, 1.0 eq) is suspended in formamide (75 mL, 1.88 mol, 8.66 eq). The resulting mixture is stirred at 140° C. for 1 h and at 170° C. for 1 h and then at 180° C. for an additional 1 h. The mixture is cooled to RT and filtered. The filter cake is washed with water, and dried in vacuo to afford the product, pyrido[3,2-d]pyrimidin-4-ol (A-2).

Workup

  1. waitat 180° C. for an additional 1 h
  2. temperatureThe mixture is cooled to RT
  3. filtrationfiltered
  4. washThe filter cake is washed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-0428f4694dea4942aad14579163f6524
Source dataset
uspto-grants-2015_03
Patent number
US08969363B2

Reaction notes

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