Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl 2-cyano-3-(pyridin-3-ylamino)acrylate | HCID 71226778 | — |
| Solvent | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Product | HCID 178510307 | HCID 178510307 | — |
Reaction Steps
The mixture of ethyl 2-cyano-3-(pyridin-3-ylamino)acrylate (C-3) (2.0 g, 9.26 mmol, 1.0 eq) in Dowtherm A (48 mL) is stirred at 260° C. for 5 h. The mixture is cooled to RT and poured into a mixture of MeOH and DCM (v/v=1:2, 20 mL). The precipitate is filtered, rinsed with DCM, and dried in vacuo to afford the product, 4-hydroxy-1,5-naphthyridine-3-carbonitrile (C-4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969363B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-2dba3005c4af41d1a204f41f12afcc9d |
|---|
| Source note | uspto-grants-2015_03 |
|---|
