Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Chloro-7-methoxyquinoline-6-carboxamide | HCID 22936418 | — |
| Reactant | ME-92 | HCID 23135084 | — |
| Solvent | Water | HCID 962 | — |
| Product | Lenvatinib | HCID 9823820 | 88% |
Reaction Steps
To dimethyl sulfoxide (20 mL) were added 7-methoxy-4-chloroquinoline-6-carboxamide (0.983 g), 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea (1.13 g) and cesium carbonate (2.71 g), and the mixture was heated and stirred at 70° C. for 23 hours. The reaction mixture was cooled to room temperature, and water (50 mL) was added, and the resultant crystals were then collected by filtration to give 1.56 g of the titled compound (yield: 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969379B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-c00c16a6d38f4385b39e06d2f2603360 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
