HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-cyclobutyl-1H-Benzimidazole → (E)-2-{8-[(2-cyclobutyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-cyclobutyl-1H-Benzimidazole | HCID 13415796 | — |
| Reactant | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| Product | (E)-2-{8-[(2-cyclobutyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile | HCID 86721336 | 90.3% |
Reaction Steps
Using 2-cyclobutyl-1H-benzo[d]imidazole (72 mg, 0.419 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (150 mg, 0.419 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (170 mg, 90%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969345B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-476bc7a43c134a83ace8ffab78d8afc0 |
| Source note | uspto-grants-2015_03 |