(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile → (E)-2-(8-{[2-(3,3-difluorocyclobutyl)-1H-benzo[d]imidazol-1-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile

Participants

Reaction Steps

[step 3] Using 2-(3,3-difluorocyclobutyl)-1H-benzo[d]imidazole (57 mg, 0.27 mmol) obtained in step 2 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (100 mg, 0.28 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (127 mg, 96%) was obtained.

Provenance & Evidence