HCID 22734831, compound → HCID 86721344, compound

HRID 869515Notes

Reaction equation

HRID 869515 reaction equation
[CH3:1][C:2]1([C:5]2[NH:9][C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[N:6]=2)[CH2:4][CH2:3]1.Br[CH2:15][C:16]1[CH:35]=[CH:34][C:19]2/[C:20](=[C:30](/[CH3:33])\[C:31]#[N:32])/[C:21]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=3[O:23][CH2:24][C:18]=2[CH:17]=1>>[F:29][C:26]1[CH:27]=[CH:28][C:21]2=[C:22]([CH:25]=1)[O:23][CH2:24][C:18]1[CH:17]=[C:16]([CH2:15][N:9]3[C:8]4[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=4[N:6]=[C:5]3[C:2]3([CH3:1])[CH2:4][CH2:3]3)[CH:35]=[CH:34][C:19]=1/[C:20]/2=[C:30](/[CH3:33])\[C:31]#[N:32]

Participants

3

Reactant 2

HCID 22734831HCID 22734831, compoundHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

Product 1

HCID 86721344HCID 86721344, compoundYield 40%

Procedure

Using 2-(1-methylcyclopropyl)-1H-benzo[d]imidazole (58 mg, 0.335 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.335 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (60 mg, 40%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-4fa9f1f635dc4ea0b3a66c2c1bf0fc86
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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