Fuberidazole → HCID 86721345, compound

HRID 869516Notes

Reaction equation

HRID 869516 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]=1.Br[CH2:16][C:17]1[CH:36]=[CH:35][C:20]2/[C:21](=[C:31](/[CH3:34])\[C:32]#[N:33])/[C:22]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=3[O:24][CH2:25][C:19]=2[CH:18]=1>>[F:30][C:27]1[CH:28]=[CH:29][C:22]2=[C:23]([CH:26]=1)[O:24][CH2:25][C:19]1[CH:18]=[C:17]([CH2:16][N:10]3[C:9]4[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=4[N:7]=[C:6]3[C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[CH:36]=[CH:35][C:20]=1/[C:21]/2=[C:31](/[CH3:34])\[C:32]#[N:33]

Participants

3

Reactant 2

HCID 19756FuberidazoleHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

Product 1

HCID 86721345HCID 86721345, compoundYield 94.4%

Procedure

Using commercially available 2-(furan-2-yl)-1H-benzo[d]imidazole (62 mg, 0.34 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.335 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (146 mg, 94%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-f82042243b8b48ec83956d1f6b6e0201
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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