4-chloro-2-cyclopropyl-1H-benzo[d]imidazole → (E)-2-{8-[(4-chloro-2-cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile

Participants

Reaction Steps

Using 4-chloro-2-cyclopropyl-1H-benzo[d]imidazole (EP1988091; 64 mg, 0.34 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.34 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (105 mg, 67%) was obtained.

Provenance & Evidence