(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile → HCID 86721369, compound

HRID 869538Notes

Reaction equation

HRID 869538 reaction equation
[CH2:1]([C:4]1[NH:5][C:6]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[N:12]=1)[CH2:2][CH3:3].Br[CH2:14][C:15]1[CH:34]=[CH:33][C:18]2/[C:19](=[C:29](/[CH3:32])\[C:30]#[N:31])/[C:20]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:21]=3[O:22][CH2:23][C:17]=2[CH:16]=1>>[F:28][C:25]1[CH:26]=[CH:27][C:20]2=[C:21]([CH:24]=1)[O:22][CH2:23][C:17]1[CH:16]=[C:15]([CH2:14][N:5]3[C:6]4[CH:11]=[CH:10][N:9]=[CH:8][C:7]=4[N:12]=[C:4]3[CH2:1][CH2:2][CH3:3])[CH:34]=[CH:33][C:18]=1/[C:19]/2=[C:29](/[CH3:32])\[C:30]#[N:31]

Participants

3

Reactant 2

HCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrileHCID 178439983HCID 178439983, compound

Product 1

HCID 86721369HCID 86721369, compoundYield 14%

Procedure

Using 2-propyl-1H-imidazo[4,5-c]pyridine (135 mg, 0.838 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (300 mg, 0.838 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (50 mg, 14%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-14d1654478b14e628e99b096c683c9a2
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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