(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile → HCID 86721370, compound

HRID 869540Notes

Reaction equation

HRID 869540 reaction equation
[Cl:1][C:2]1[C:7]2[N:8]=[C:9]([CH:11]3[CH2:14][CH2:13][CH2:12]3)[NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1.Br[CH2:16][C:17]1[CH:36]=[CH:35][C:20]2/[C:21](=[C:31](/[CH3:34])\[C:32]#[N:33])/[C:22]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=3[O:24][CH2:25][C:19]=2[CH:18]=1>>[Cl:1][C:2]1[C:7]2[N:8]=[C:9]([CH:11]3[CH2:14][CH2:13][CH2:12]3)[N:10]([CH2:16][C:17]3[CH:36]=[CH:35][C:20]4/[C:21](=[C:31](/[CH3:34])\[C:32]#[N:33])/[C:22]5[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=5[O:24][CH2:25][C:19]=4[CH:18]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrileHCID 86721371HCID 86721371, compound

Product 1

HCID 86721370HCID 86721370, compoundYield 91.5%

Procedure

[step 3] Using 4-chloro-2-cyclobutyl-1H-imidazo[4,5-c]pyridine (41 mg, 0.196 mmol) obtained in step 2 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (70 mg, 0.196 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (87 mg, 91%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-9f4d0adb109c4122828288c4e6ed1e0c
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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