(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile → HCID 86721372, compound

HRID 869541Notes

Reaction equation

HRID 869541 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][C:9]([CH:11]3[CH2:13][CH2:12]3)=[N:10][C:3]=12.Br[CH2:15][C:16]1[CH:35]=[CH:34][C:19]2/[C:20](=[C:30](/[CH3:33])\[C:31]#[N:32])/[C:21]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=3[O:23][CH2:24][C:18]=2[CH:17]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([CH2:15][C:16]3[CH:35]=[CH:34][C:19]4/[C:20](=[C:30](/[CH3:33])\[C:31]#[N:32])/[C:21]5[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=5[O:23][CH2:24][C:18]=4[CH:17]=3)[C:9]([CH:11]3[CH2:13][CH2:12]3)=[N:10][C:3]=12

Participants

3

Reactant 2

HCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrileHCID 178478245HCID 178478245, compound

Product 1

HCID 86721372HCID 86721372, compoundYield 54.2%

Procedure

Using 7-chloro-2-cyclopropyl-3H-imidazo[4,5-b]pyridine (EP1988091, 81 mg, 0.419 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (150 mg, 0.419 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (107 mg, 54%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-d4e65341776241b58a8e63c2c872effb
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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