HCID 86721376, compound → HCID 86721374, compound

HRID 869543Notes

Reaction equation

HRID 869543 reaction equation
[F:1][C:2]1[N:7]=[C:6]2[NH:8][C:9]([CH2:11][CH2:12][CH3:13])=[N:10][C:5]2=[CH:4][CH:3]=1.[F:14][C:15]1[CH:16]=[CH:17][C:18]2=[C:19]([CH:35]=1)[O:20][CH2:21][C:22]1[CH:32]=[C:31]([CH2:33]O)[CH:30]=[CH:29][C:23]=1/[C:24]/2=[C:25](/[CH3:28])\[C:26]#[N:27]>>[F:14][C:15]1[CH:16]=[CH:17][C:18]2=[C:19]([CH:35]=1)[O:20][CH2:21][C:22]1[CH:32]=[C:31]([CH2:33][N:8]3[C:6]4=[N:7][C:2]([F:1])=[CH:3][CH:4]=[C:5]4[N:10]=[C:9]3[CH2:11][CH2:12][CH3:13])[CH:30]=[CH:29][C:23]=1/[C:24]/2=[C:25](/[CH3:28])\[C:26]#[N:27]

Participants

3

Reactant 2

HCID 86721376HCID 86721376, compoundHCID 178439933HCID 178439933, compound

Product 1

HCID 86721374HCID 86721374, compoundYield 42.3%

Procedure

[step 3] Using 5-fluoro-2-propyl-3H-imidazo[4,5-b]pyridine (47 mg, 0.262 mmol) obtained in step 2 and (E)-2-[3-fluoro-8-(hydroxymethyl)dibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (70 mg, 0.238 mmol) obtained in Reference Example 1, step 5, and in the same manner as in Reference Example 3E, the title compound (46 mg, 42%) was obtained.

Workup

  1. customobtained in Reference Example 1, step 5

Sources & evidence

ORD record
ord-47466c385f224087aaefa64d14ebe055
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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