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2-(azetidin-1-yl)-1H-benzo[d]imidazole → (E)-2-(8-{[2-(azetidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(azetidin-1-yl)-1H-benzo[d]imidazole | HCID 59605883 | — |
| 反応物 | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| 生成物 | (E)-2-(8-{[2-(azetidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile | HCID 86721383 | 59% |
反応手順
[step 2] Using 2-(azetidin-1-yl)-1H-benzo[d]imidazole (40 mg, 0.23 mmol) obtained in step 1 and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (84 mg, 0.24 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (61 mg, 59%) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08969345B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-e9fe6462aa9c4ba2a6e88065de5c1d9a |
| 出典メモ | uspto-grants-2015_03 |