2-(Piperidin-1-yl)-1H-benzimidazole → HCID 86721385, compound

HRID 869552Notes

Reaction equation

HRID 869552 reaction equation
[N:1]1([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:17][C:18]1[CH:37]=[CH:36][C:21]2/[C:22](=[C:32](/[CH3:35])\[C:33]#[N:34])/[C:23]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:24]=3[O:25][CH2:26][C:20]=2[CH:19]=1>>[F:31][C:28]1[CH:29]=[CH:30][C:23]2=[C:24]([CH:27]=1)[O:25][CH2:26][C:20]1[CH:19]=[C:18]([CH2:17][N:11]3[C:10]4[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=4[N:8]=[C:7]3[N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[CH:37]=[CH:36][C:21]=1/[C:22]/2=[C:32](/[CH3:35])\[C:33]#[N:34]

Participants

3

Reactant 2

HCID 2702912-(Piperidin-1-yl)-1H-benzimidazoleHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

Product 1

HCID 86721385HCID 86721385, compoundYield 78%

Procedure

Using commercially available 2-(piperidin-1-yl)-1H-benzo[d]imidazole (67 mg, 0.34 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.34 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (125 mg, 78%) was obtained.

Workup

  1. customobtained in Reference Example 1

Sources & evidence

ORD record
ord-6e81775764994a32aa75e64db292879f
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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