4-chloro-2-cyclopropyl-1H-benzo[d]imidazole → (E)-2-{8-[(4-chloro-2-cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}-2-cyclopropylacetonitrile

Participants

Reaction Steps

Using 4-chloro-2-cyclopropyl-1H-benzo[d]imidazole (EP1988091, 60 mg, 0.31 mmol) and (E)-2-(8-bromomethyl-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)-2-cyclopropylacetonitrile (120 mg, 0.31 mmol) obtained in Reference Example 6, and in the same manner as in Reference Example 1A, the title compound (115 mg, 74%) was obtained.

Provenance & Evidence