HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(methoxymethyl)-1H-benzimidazole → (E)-2-(3-fluoro-8-{[2-(methoxymethyl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)butanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(methoxymethyl)-1H-benzimidazole | HCID 242950 | — |
| Reactant | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]butanenitrile | HCID 86721392 | — |
| Product | (E)-2-(3-fluoro-8-{[2-(methoxymethyl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)butanenitrile | HCID 86721391 | 100.3% |
Reaction Steps
Using 2-(methoxymethyl)-1H-benzo[d]imidazole (61 mg, 0.376 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]butanenitrile (140 mg, 0.376 mmol) obtained in Reference Example 8, and in the same manner as in Reference Example 1A, the title compound (171 mg, 100%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969345B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-de61a6cb97564df3a110feb5a335cb58 |
| Source note | uspto-grants-2015_03 |