Methanol → HCID 3435423, compound

HRID 869566Notes

Reaction equation

HRID 869566 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1.[CH3:12][OH:13].C[O-].[Na+]>O>[CH3:12][O:13][CH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 9576142-Chloromethyl-imidazo(1,2-A)pyridineHCID 10942334Sodium Methoxide

Product 1

HCID 3435423HCID 3435423, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

[step 2] To 2-(chloromethyl)imidazo[1,2-a]pyridine (4.04 g, 24 mmol) obtained in step 1 were added methanol (121 mL) and sodium methoxide (3.93 g, 73 mmol), and the mixture was stirred at 50° C. for 6 hr. The reaction was discontinued with water, and the mixture was extracted with chloroform and the extract was dried over sodium sulfate. Filtration and concentration under reduced pressure gave 2-(methoxymethyl)imidazo[1,2-a]pyridine (3.45 g, 88%).

Workup

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialthe extract was dried over sodium sulfate
  3. filtrationFiltration and concentration under reduced pressure

Sources & evidence

ORD record
ord-a48305fa2be146c19c3912dd6934929a
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

Loading…