反应详情

[step 4] Using 8-methoxy-3-iodo-2-(methoxymethyl)imidazo[1,2-a]pyridine (500 mg, 1.57 mmol) obtained in step 3 and (E)-2-(3-fluoro-8-formyldibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (230 mg, 0.786 mmol) obtained in Reference Example 5, and in the same manner as in Reference Example 8F, step 4, (E)-2-(3-fluoro-8-{hydroxy[8-methoxy-2-(methoxymethyl)imidazo[1,2-a]pyridin-3-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (250 mg, 66%) was obtained.

1. customobtained in Reference Example 5