HRID869576

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C/C(C#N)=C1/c2ccc(C=O)cc2COc2cc(F)ccc21

HCID86721404

未命名化合物

HCID86721419

未命名化合物

PRODUCTS

生成物

$结构：COCc1nc2c(OC(F)F)cccn2c1C(O)c1ccc2c(c1)COc1cc(F)ccc1/C2=C(\C)C#N$

HCID86721418

未命名化合物

收率 78%

PROCEDURE

实验过程

[step 4] Using 8-(difluoromethoxy)-3-iodo-2-(methoxymethyl)imidazo[1,2-a]pyridine (700 mg, 1.98 mmol) obtained in step 3 and (E)-2-(3-fluoro-8-formyldibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (290 mg, 0.988 mmol) obtained in Reference Example 5, and in the same manner as in Reference Example 8F, step 4, (E)-2-(8-{[8-(difluoromethoxy)-2-(methoxymethyl)imidazo[1,2-a]pyridin-3-yl](hydroxy)methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (400 mg, 78%) was obtained.

WORKUP

后处理

customobtained in Reference Example 5