(E)-2-(3-fluoro-8-formyldibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile → HCID 86721432, compound

Participants

Reaction Steps

[step 3] Using 2-cyclopropyl-3-iodo-8-(trifluoromethyl)imidazo[1,2-a]pyridine (480 mg, 1.36 mmol) obtained in step 2 and (E)-2-(3-fluoro-8-formyldibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (200 mg, 0.68 mmol) obtained in Reference Example 5, and in the same manner as in Reference Example 8A, step 3, (E)-2-(8-{[2-cyclopropyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl](hydroxy)methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (356 mg) was obtained quantitatively.

Provenance & Evidence