HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole, 2-propyl- → (E)-2-{3-fluoro-8-[(2-propyl-1H-indol-3-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole, 2-propyl- | HCID 139415 | — |
| Reactant | (E)-2-(3-fluoro-8-formyldibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile | HCID 86721404 | — |
| Product | (E)-2-{3-fluoro-8-[(2-propyl-1H-indol-3-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile | HCID 86721438 | 55.1% |
Reaction Steps
[step 5] Using 2-propyl-1H-indole (100 mg, 0.64 mmol) obtained in step 4 and (E)-2-(3-fluoro-8-formyldibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (153 mg, 0.52 mmol) obtained in Reference Example 5, and in the same manner as in Reference Example 13A, the target compound (125 mg, 55%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969345B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4db0b3296ee545c9881745a98ee45a25 |
| Source note | uspto-grants-2015_03 |