HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-methoxyacetoacetate → HCID 86721449, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-methoxyacetoacetate | HCID 123500 | — |
| Reactant | (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile | HCID 86721333 | — |
| Product | HCID 86721449 | HCID 86721449 | 83% |
Reaction Steps
[step 1] Using methyl 4-methoxy-3-oxobutanoate (816 mg, 5.58 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (1.0 g, 2.79 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 13G, step 1, (E)-methyl 2-{[11-(1-cyanoethylidene)-3-fluoro-6,11-dihydrodibenzo[b,e]oxepin-8-yl]methyl}-4-methoxy-3-oxobutanoate (977 mg, 83%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969345B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-299d8aa6c820458c886f65c1e336b615 |
| Source note | uspto-grants-2015_03 |