Dimethylamine methanol → HCID 86721450, compound

HRID 869599Notes

Reaction equation

Cl[C:2]1[C:7]([CH2:8][C:9]2[CH:28]=[CH:27][C:12]3/[C:13](=[C:23](/[CH3:26])\[C:24]#[N:25])/[C:14]4[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:15]=4[O:16][CH2:17][C:11]=3[CH:10]=2)=[C:6]([CH2:29][O:30][CH3:31])[N:5]=[C:4]([CH3:32])[N:3]=1.CO.[CH3:35][NH:36][CH3:37]>>[CH3:35][N:36]([CH3:37])[C:2]1[C:7]([CH2:8][C:9]2[CH:28]=[CH:27][C:12]3/[C:13](=[C:23](/[CH3:26])\[C:24]#[N:25])/[C:14]4[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:15]=4[O:16][CH2:17][C:11]=3[CH:10]=2)=[C:6]([CH2:29][O:30][CH3:31])[N:5]=[C:4]([CH3:32])[N:3]=1

Participants

Reactant 2

HCID 22497844Dimethylamine methanol

HCID 86721451HCID 86721451, compound

Product 1

HCID 86721450HCID 86721450, compoundYield 57.4%

Procedure

[step 4] Using (E)-2-(8-{[4-chloro-6-(methoxymethyl)-2-methylpyrimidin-5-yl]methyl}-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile (164 mg, 0.365 mmol) obtained in step 3 and 2 mol/L dimethylamine methanol solution (1.28 mL, 2.55 mmol), and in the same manner as in Reference Example 13G, step 4, the title compound (96 mg, 56%) was obtained.

Sources & evidence

ORD record: ord-cc36b64858454fdb9b76b69b12da3bd1
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08969345B2

Reaction notes

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