2-(Di-tert-butylphosphino)biphenyl → HCID 86721469, compound

Participants

Reaction Conditions

Reaction Steps

(E)-2-{8-[(8-bromo-2-cyclopropylimidazo[1,2-a]pyridin-3-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile (0.36 g, 0.69 mmol) obtained in Reference Example 14C, step 4 was dissolved in toluene (14 mL), Pd2(dba)3 (0.13 g, 0.14 mmol), 2-(di-tert-butylphosphino)biphenyl (0.04 g, 0.14 mmol), sodium tert-butoxide (0.13 g, 1.4 mmol) and 2 mol/L dimethylamine THF solution (4.5 mL, 9.0 mmol) were added, and the mixture was stirred with heating at 120° C. for 2.5 hr in an Emrys Optimizer microwave synthesizer. The mixture was filtered through celite, the filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (heptane/ethyl acetate=100/0 v/v-70/30 v/v) to give the title compound (0.10 g, 29%).

Provenance & Evidence