Ethyl bromopyruvate → HCID 86721477, compound

HRID 869614Notes

Reaction equation

HRID 869614 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][N:3]=1.Br[CH2:10][C:11](=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13]>>[F:8][C:6]1[CH:5]=[CH:4][N:3]2[CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:1]=[C:2]2[CH:7]=1

Participants

3

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 183278082-Amino-4-fluoropyridine

Product 1

HCID 86721477HCID 86721477, compoundYield 59%

Procedure

[step 1] Using 2-amino-4-fluoropyridine (3.2 g, 28.5 mmol) and ethyl bromopyruvate (4.3 ml, 34.3 mmol), and in the same manner as in Reference Example 8A, step 1, ethyl 7-fluoroimidazo[1,2-a]pyridine-2-carboxylate (3.5 g, 59%) was obtained.

Sources & evidence

ORD record
ord-512453fafc42488f9f390c15ec67b66d
Source dataset
uspto-grants-2015_03
Patent number
US08969345B2

Reaction notes

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