Indole-2-carboxylic acid → HCID 178513799, compound

HRID 869632Notes

Reaction equation

HRID 869632 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:5]=[C:6]([O:13][CH2:14][C@H:15]2[CH2:19][CH2:18][CH2:17][NH:16]2)[C:7]([C:10]([NH2:12])=[O:11])=[N:8][CH:9]=1.[F:20][C:21]([F:32])([F:31])[C@@H:22]1[CH2:27][CH2:26][C@H:25]([C:28](O)=[O:29])[CH2:24][CH2:23]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[Cl:3][C:4]1[CH:5]=[C:6]([O:13][CH2:14][C@H:15]2[CH2:19][CH2:18][CH2:17][N:16]2[C:28]([C@H:25]2[CH2:24][CH2:23][C@@H:22]([C:21]([F:20])([F:31])[F:32])[CH2:27][CH2:26]2)=[O:29])[C:7]([C:10]([NH2:12])=[O:11])=[N:8][CH:9]=1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 66962076(R)-5-chloro-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochlorideHCID 178525709HCID 178525709, compound

Product 1

HCID 178513799HCID 178513799, compound

Procedure

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 3 using (R)-5-chloro-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride (EXAMPLE 29 Step 5) and cis-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-147c8998cbb749dd9af5c56eb8eaa39f
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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