Indole-2-carboxylic acid → HCID 178520946, compound

HRID 869634Notes

Reaction equation

HRID 869634 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].[F:8][C:9]([F:20])([F:19])[C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16](O)=[O:17])[CH2:12][CH2:11]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[F:8][C:9]([F:19])([F:20])[C@H:10]1[CH2:11][CH2:12][C@H:13]([C:16]([N:1]2[CH2:5][CH2:4][CH2:3][C@@H:2]2[CH2:6][OH:7])=[O:17])[CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 2724541Prolinol, (R)-HCID 178525710HCID 178525710, compound

Product 1

HCID 178520946HCID 178520946, compound

Procedure

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 3 using (R)-pyrrolidin-2-ylmethanol and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-d1139769b746440bbc81200bd917b39b
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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