(R)-N-(2-hydroxyethyl)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride → HCID 178523455, compound

HRID 869643Notes

Reaction equation

HRID 869643 reaction equation
Cl.Cl.[OH:3][CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[C:13]([O:14][CH2:15][C@H:16]2[CH2:20][CH2:19][CH2:18][NH:17]2)=[CH:12][CH:11]=[CH:10][N:9]=1.[F:22][C:23]([F:34])([F:33])[C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](O)=[O:31])[CH2:26][CH2:25]1.COC1C=C(OC[C@H]2CCCN2C([C@H]2CC[C@H](C(F)(F)F)CC2)=O)C(C(O)=O)=NC=1>>[OH:3][CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[C:13]([O:14][CH2:15][C@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[C:30]([C@H:27]2[CH2:26][CH2:25][C@H:24]([C:23]([F:22])([F:33])[F:34])[CH2:29][CH2:28]2)=[O:31])=[CH:12][CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 3

HCID 66962029(R)-N-(2-hydroxyethyl)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochlorideHCID 178493765HCID 178493765, compoundHCID 178525710HCID 178525710, compound

Product 1

HCID 178523455HCID 178523455, compound

Procedure

The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)—N-(2-hydroxyethyl)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride (EXAMPLE 33 Step 4) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid.

Sources & evidence

ORD record
ord-5f8ec3e1b90642a9a08140e7b8a0f829
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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