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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869651Generated: October 25, 2026

3-(Trifluoromethyl)benzoic acid → (R)-ethyl 3-((1-(3-(trifluoromethyl)benzoyl)pyrrolidin-2-yl)methoxy)picolinate

https://huagongshe.com/reaction/869651

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzoic acidHCID 9963—
Reactant(R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinateHCID 86666098—
ReactantHCID 178493765HCID 178493765—
Product(R)-ethyl 3-((1-(3-(trifluoromethyl)benzoyl)pyrrolidin-2-yl)methoxy)picolinateHCID 86666101—

Reaction Steps

The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinate bis(trifuluoroacetic acid) salt (EXAMPLE 34 Step 1) and 3-trifluoromethylbenzoic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08969383B2
Source datasetuspto-grants-2015_03
ORD IDord-5cfe030c02cd4b1190310e70f122161f
Source noteuspto-grants-2015_03