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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 869655Generated: October 30, 2026

3-(Trifluoromethyl)benzoic acid → (R)-3-((1-(3-(trifluoromethyl)benzoyl)pyrrolidin-2-yl)methoxy)picolinamide

https://huagongshe.com/reaction/869655

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzoic acidHCID 9963—
Reactant(R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochlorideHCID 66960633—
ReactantHCID 178493765HCID 178493765—
Product(R)-3-((1-(3-(trifluoromethyl)benzoyl)pyrrolidin-2-yl)methoxy)picolinamideHCID 66962170—

Reaction Steps

The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride (EXAMPLE 1 Step 3) and 3-(trifluoromethyl)benzoic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08969383B2
Source datasetuspto-grants-2015_03
ORD IDord-83f7c00a5880497e8e31c2f72036f9a8
Source noteuspto-grants-2015_03