2-Aminooxazole → HCID 178522548, compound

HRID 869663Notes

Reaction equation

HRID 869663 reaction equation
[CH2:1]([O:8][CH2:9][O:10][C@H:11]1[CH2:15][N:14]([C:16]([C@H:18]2[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]2)=[O:17])[C@@H:13]([CH2:28][O:29][C:30]2[C:31]([C:36]([OH:38])=O)=[N:32][CH:33]=[CH:34][CH:35]=2)[CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:39]1[CH:43]=[CH:42][N:41]=[C:40]1[NH2:44].Cl.Cl.N1CCC[C@@H]1COC1C(C(N)=O)=NC=CC=1>>[CH2:1]([O:8][CH2:9][O:10][C@H:11]1[CH2:15][N:14]([C:16]([C@H:18]2[CH2:19][CH2:20][C@H:21]([C:24]([F:25])([F:26])[F:27])[CH2:22][CH2:23]2)=[O:17])[C@@H:13]([CH2:28][O:29][C:30]2[C:31]([C:36]([NH:44][C:40]3[O:39][CH:43]=[CH:42][N:41]=3)=[O:38])=[N:32][CH:33]=[CH:34][CH:35]=2)[CH2:12]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 5585212-AminooxazoleHCID 66960633(R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochlorideHCID 178524886HCID 178524886, compound

Product 1

HCID 178522548HCID 178522548, compound

Procedure

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 3 using 3-(((2R,4R)-4-(benzyloxymethoxy)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinic acid (EXAMPLE 79 Step 6) and oxazol-2-amine instead of indole-2-carboxylic acid and (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride.

Sources & evidence

ORD record
ord-d51972e0044c431bbf372c332f45d934
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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