Indole-2-carboxylic acid → HCID 178470237, compound

HRID 869667Notes

Reaction equation

HRID 869667 reaction equation
Cl.Cl.[CH3:3][C:4]1([CH2:9][O:10][C:11]2[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=2)[CH2:8][CH2:7][NH:6][CH2:5]1.[F:22][C:23]([F:34])([F:33])[C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](O)=[O:31])[CH2:26][CH2:25]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[CH3:3][C:4]1([CH2:9][O:10][C:11]2[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=2)[CH2:8][CH2:7][N:6]([C:30]([C@H:27]2[CH2:26][CH2:25][C@H:24]([C:23]([F:22])([F:33])[F:34])[CH2:29][CH2:28]2)=[O:31])[CH2:5]1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 66961840Ethyl 3-((3-methylpyrrolidin-3-yl)methoxy)picolinate dihydrochlorideHCID 178525710HCID 178525710, compound

Product 1

HCID 178470237HCID 178470237, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 1 using ethyl 3-((3-methylpyrrolidin-3-yl)methoxy)picolinate dihydrochloride (EXAMPLE 86, Step 2) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-5ad8fa2297d14364bbc41310681e0300
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

Loading…