HCID 178470237, compound → HCID 178431205, compound

HRID 869668Notes

Reaction equation

HRID 869668 reaction equation
[CH3:1][C:2]1([CH2:19][O:20][C:21]2[C:22]([C:27]([O:29]CC)=[O:28])=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:6][CH2:5][N:4]([C:7]([C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:8])[CH2:3]1.COC1C=C(OC[C@H]2CCCN2C([C@H]2CC[C@H](C(F)(F)F)CC2)=O)C(C(OCC)=O)=NC=1>>[CH3:1][C:2]1([CH2:19][O:20][C:21]2[C:22]([C:27]([OH:29])=[O:28])=[N:23][CH:24]=[CH:25][CH:26]=2)[CH2:6][CH2:5][N:4]([C:7]([C@H:9]2[CH2:10][CH2:11][C@H:12]([C:15]([F:18])([F:16])[F:17])[CH2:13][CH2:14]2)=[O:8])[CH2:3]1

Participants

3

Reactant 2

HCID 178470237HCID 178470237, compoundHCID 178470258HCID 178470258, compound

Product 1

HCID 178431205HCID 178431205, compound

Procedure

The title compound was prepared according to the procedure described in Step 4 of EXAMPLE 31 using ethyl 3-((3-methyl-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-3-yl)methoxy)picolinate (EXAMPLE 86 Step 3) in stead of ethyl 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinate.

Sources & evidence

ORD record
ord-b4838629ed7b46df826ff58073df0fb1
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

Loading…