Indole-2-carboxylic acid → HCID 178470235, compound

HRID 869669Notes

Reaction equation

HRID 869669 reaction equation
Cl.Cl.[C:3]12([CH2:9][O:10][C:11]3[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=3)[CH2:8][CH:7]1[CH2:6][NH:5][CH2:4]2.[F:22][C:23]([F:34])([F:33])[C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30](O)=[O:31])[CH2:26][CH2:25]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[F:22][C:23]([F:33])([F:34])[C@H:24]1[CH2:25][CH2:26][C@H:27]([C:30]([N:5]2[CH2:6][CH:7]3[C:3]([CH2:9][O:10][C:11]4[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=4)([CH2:8]3)[CH2:4]2)=[O:31])[CH2:28][CH2:29]1

Participants

4

Reactant 3

HCID 72899Indole-2-carboxylic acidHCID 66961850Ethyl 3-(3-azabicyclo[3.1.0]hexan-1-ylmethoxy)picolinate dihydrochlorideHCID 178525710HCID 178525710, compound

Product 1

HCID 178470235HCID 178470235, compound

Procedure

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 1 using ethyl 3-(3-azabicyclo[3.1.0]hexan-1-ylmethoxy)picolinate dihydrochloride (EXAMPLE 88, Step 2) and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-97f07051260245d1a404184f8a4a804d
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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