HCID 178470235, compound → HCID 178524883, compound

HRID 869670Notes

Reaction equation

HRID 869670 reaction equation
[F:1][C:2]([F:31])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([N:11]2[CH2:16][CH:15]3[C:13]([CH2:17][O:18][C:19]4[C:20]([C:25]([O:27]CC)=[O:26])=[N:21][CH:22]=[CH:23][CH:24]=4)([CH2:14]3)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1.COC1C=C(OC[C@H]2CCCN2C([C@H]2CC[C@H](C(F)(F)F)CC2)=O)C(C(OCC)=O)=NC=1>>[F:31][C:2]([F:1])([F:30])[C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([N:11]2[CH2:16][CH:15]3[C:13]([CH2:17][O:18][C:19]4[C:20]([C:25]([OH:27])=[O:26])=[N:21][CH:22]=[CH:23][CH:24]=4)([CH2:14]3)[CH2:12]2)=[O:10])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 178470235HCID 178470235, compoundHCID 178470258HCID 178470258, compound

Product 1

HCID 178524883HCID 178524883, compound

Procedure

The title compound was prepared according to the procedure described in Step 4 of EXAMPLE 31 using ethyl 3-((3-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)-3-azabicyclo[3.1.0]hexan-1-yl)methoxy)picolinate (EXAMPLE 88 Step 3) in stead of ethyl 5-methoxy-3-(((R)-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)methoxy)picolinate.

Sources & evidence

ORD record
ord-34bdfcbcdd614b9c9225f058c244ebf9
Source dataset
uspto-grants-2015_03
Patent number
US08969383B2

Reaction notes

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