Triethylamine → HCID 86674506, compound

Participants

Reaction Steps

To a suspension of 3-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)-2-methylquinoxaline (991 mg, 3.00 mmol), 4-aminotetrahydropyran (364 mg, 3.60 mmol), and triethylamine (1.25 mL, 9.00 mmol) in N,N-dimethylformamide (30 mL) was stirred for 2 h at room temperature. After being cooled to 0° C., the reaction mixture was diluted with water. The resulting precipitate was collected and purified by silica gel column chromatography (silica gel 200 g, chloroform to chloroform:ethyl acetate=1:1) to give 5-chloro-2-(3-methylquinoxalin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine. MS (APCI): m/z 395/397 (M+H).

Provenance & Evidence