Hydrochloric Acid → HCID 71073924, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-(3-methylquinoxalin-2-yl)-5-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine (655 mg, 1.52 mmol) in ethanol (15 mL) was added 2N aqueous hydrochloric acid solution (0.915 mL). The mixture was heated at 80° C. for 3 h, and then water (3.1 mL) and ethanol (5.0 mL) was added. The mixture was clear solution and then cooled to ambient temperature to give 2-(3-methylquinoxalin-2-yl)-5-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine hydrochloride (the compound of Example 1.001 listed in the Table of Examples as described hereinafter). 1H-NMR (500 MHz, DMSO-d6): δ 1.86-1.91 (4H, m), 2.04-2.06 (4H, m), 3.08 (3H, s), 3.46-3.53 (2H, m), 3.63 (4H, m), 3.94 (2H, m), 4.09 (1H, m), 5.62 (1H, s), 6.87 (1H, s), 7.83-7.90 (2H, m), 8.08 (1H, dd, J=8.2, 1.4 Hz), 8.14 (1H, dd, J=8.0, 1.3 Hz), 8.20 (1H, br).

Provenance & Evidence