4-(Methylamino)tetrahydro-2H-pyran → HCID 117917563, compound

HRID 869683Notes

Reaction equation

HRID 869683 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[C:13]([CH3:22])=[N:14][C:15]4[C:20]([N:21]=3)=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:11]=[C:4]2[N:3]=1.[CH3:23][NH:24][CH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:24]([CH3:23])[CH:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[N:5]2[N:9]=[C:10]([C:12]3[C:13]([CH3:22])=[N:14][C:15]4[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=4)[N:21]=3)[CH:11]=[C:6]2[CH:7]=1

Participants

3

Reactant 2

HCID 69919504-(Methylamino)tetrahydro-2H-pyranHCID 76683610HCID 76683610, compound

Product 1

HCID 117917563HCID 117917563, compound

Procedure

The preparation was performed in a similar manner as Example 1.001 (g) from 3-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)-2-methylquinoxaline (200 mg, 0.606 mmol) and N-methyl-4-aminotetrahydropyran (84 mg, 0.729 mmol) to give 5-chloro-N-methyl-2-(3-methylquinoxalin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-c]pyrimidin-7-amine. MS (APCI): m/z 409/411 (M+H).

Sources & evidence

ORD record
ord-ccac5a92591542bd91742640a37da08c
Source dataset
uspto-grants-2015_03
Patent number
US08969376B2

Reaction notes

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