Water → HCID 58328048, compound

Participants

Reaction Steps

Preparation was performed in a similar manner as Example 1.001 (a). To a solution of tert-butyl (E)-[(1E)-1-ethyl-3-methoxy-3-oxoprop-1-en-1-yl]diazenecarboxylate (see Synlett. 2003, 8, 1183; 1.50 g, 6.19 mmol) in tetrahydrofuran (30 mL) was added 1,2-phenylenediamine (683 mg, 6.19 mmol) at room temperature. After being stirred for 22 hour, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was combined and dried over magnesium sulfate, filtrated and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane to hexane:ethyl acetate=6:1) to give ethyl 3-ethylquinoxaline-2-carboxylate. MS (APCI): m/z 217 (M+H).

Provenance & Evidence